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Developmental influences on vascular structure and function.

J A Bevan, R D Bevan

    Ciba Foundation Symposium
    |January 1, 1981
    PubMed
    Summary
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    Vessel function varies greatly, even with similar structures. Early development and sympathetic nerve activity during growth significantly shape the unique characteristics and long-term function of adult blood vessels.

    Area of Science:

    • Cardiovascular Physiology
    • Developmental Biology
    • Vascular Biology

    Background:

    • Blood vessels exhibit significant functional heterogeneity despite structural similarities.
    • The basis for these functional differences in vascular beds remains largely unknown.
    • Early embryological development patterns may influence specific vascular characteristics.

    Purpose of the Study:

    • To investigate the developmental origins of functional heterogeneity in blood vessels.
    • To explore the role of embryological development and early life factors in determining mature vascular function.
    • To understand the long-term impact of sympathetic nerve activity on vascular development and reactivity.

    Main Methods:

    • Comparative analysis of vascular structures and functions.

    Related Experiment Videos

  • Examination of embryological development patterns and mesenchymal origins.
  • Studies on fetal lambs to confirm early establishment of vascular individuality.
  • Experiments on rabbit ear artery to assess sympathetic nerve traffic influence.

    • Main Results:

    • Vascular functional characteristics are established early in development, potentially during gastrulation.
    • Mesenchymal origins correlate with specific receptor characteristics and tissue sensitivities.
    • Sympathetic nerve traffic during growth influences vascular smooth muscle cell function, structure, and reactivity.
    • Early sympathetic nerve activity exerts a long-term influence on blood pressure regulation.

    Conclusions:

    • The functional individuality of blood vessels is determined early in development.
    • Embryological origins and early life environmental factors, including sympathetic innervation, shape adult vascular properties.
    • Understanding these early influences is crucial for comprehending vascular health and disease.