Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ACTH and alpha-melanotropin in central temperature control.

J M Lipton, J R Glyn, J A Zimmer

    Federation Proceedings
    |November 1, 1981
    PubMed
    Summary

    Adrenocorticotropin (ACTH) and alpha-melanotropin (alpha-MSH) reduce body temperature by inhibiting heat production and conservation pathways. These peptides also act as antipyretics, potentially modulating fever responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of MERV 16 and HEPA filters for cab filtration of underground mining equipment.

    Mining engineering·2016
    Same author

    Air cleaning performance of a new environmentally controlled primary crusher operator booth.

    Mining engineering·2016
    Same author

    Reduced febrile responses to peripheral and central administration of pyrogen in aged squirrel monkeys.

    Neurobiology of aging·2013
    Same author

    Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2.

    The journal of peptide research : official journal of the American Peptide Society·2005
    Same author

    Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup.

    Leukemia·2003
    Same author

    Thrombocytopenia absent corpus callosum syndrome: third case of a distinct clinical entity.

    Journal of pediatric hematology/oncology·2002

    Area of Science:

    • Neuroendocrinology
    • Thermoregulation
    • Physiology

    Background:

    • Adrenocorticotropin (ACTH) and alpha-melanotropin (alpha-MSH) are present in brain regions critical for temperature regulation.
    • These peptides are known to influence body temperature.
    • Their precise roles in thermoregulation and fever are not fully elucidated.

    Purpose of the Study:

    • To investigate the hypothermic and antipyretic effects of ACTH and alpha-MSH.
    • To determine the mechanisms underlying these effects, including their independence from adrenal stimulation.
    • To explore the potential role of these peptides in central thermoregulatory pathways.

    Main Methods:

    • Central administration of ACTH and alpha-MSH in animal models (rabbits, squirrel monkeys).
    • Observation of effects on normal body temperature and experimentally induced fever.
    • Assessment of effects in adrenalectomized animals to differentiate central from peripheral actions.

    Main Results:

    • Central injection of ACTH and alpha-MSH induced hypothermia without altering the temperature set point.
    • These peptides demonstrated antipyretic properties at doses that did not affect normal body temperature.
    • The hypothermic and antipyretic effects were observed in adrenalectomized rabbits, indicating a central mechanism.
    • Comparable antipyretic effects were noted in squirrel monkeys.

    Conclusions:

    • ACTH and alpha-MSH act centrally to inhibit heat conservation and production pathways, leading to hypothermia.
    • These peptides possess significant antipyretic capabilities, potentially limiting fever responses.
    • Their actions are independent of adrenal cortex stimulation, suggesting a direct role in central thermoregulation.
    • ACTH and alpha-MSH may function as neurotransmitters or neuromodulators in central thermoregulatory pathways, influencing both normal temperature and fever.

    Related Experiment Videos