[Pharmacokinetics of ceftizoxim (author's transl)]

Ceftizoxim is a new cephalosporin derivative, which is also effective against anaerobic rods. The tolerability is excellent. Its pharmacokinetics after parenteral administration of 2 g were investigated in 12 healthy male volunteers. The half-life was 1.40 +/- 0.41 hours, the total clearance 194 l/min. The urinary excretion of the biological effective antibiotic amounted to 66.26 +/- 25.71%. These figures are in the same order of magnitude as those of older cephalosporins.