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Ascorbate oxidase and its possible involvement in cancer.

Zeitschrift Fur Naturforschung. Section C, Biosciences

|September 1, 1981

Summary

Ascorbic acid (vitamin C) administration increased spin concentration in erythrocytes, suggesting a specific reaction. This effect was reversed by ascorbate oxidase, indicating its role in vitamin C metabolism and potential links to certain cancers.

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Area of Science:

Biochemistry
Medical Science
Biophysics

Background:

Ascorbic acid (vitamin C) is a vital antioxidant.
Electron spin resonance (ESR) can detect free radicals.
Previous research linked a specific ESR signal to the semidehydroascorbate (SDA) radical.

Purpose of the Study:

To investigate the in vivo and in vitro effects of ascorbic acid on erythrocyte spin concentration.
To explore the role of ascorbate oxidase in ascorbic acid metabolism.
To examine the potential correlation between ascorbate oxidase levels and specific cancer types.

Main Methods:

Intravenous administration of ascorbic acid to a healthy volunteer.
Electron spin resonance (ESR) spectroscopy of erythrocytes.
In vitro addition of ascorbate oxidase to erythrocytes and lung cancer tissue samples.
Measurement of vitamin C concentration in erythrocytes and plasma.

Main Results:

Intravenous ascorbic acid increased erythrocyte spin concentration and generated a unique g-2.005 signal (SDA radical).
Vitamin C levels were significantly elevated in erythrocytes and plasma post-administration.
In vitro addition of ascorbate oxidase reversed the ascorbic acid-induced changes in spin concentration and SDA signal.

Conclusions:

A substance, likely ascorbate oxidase, specifically reacts with ascorbic acid, influencing its metabolism.
Diminished ascorbate oxidase concentration may be associated with certain cancers like acute lymphatic leukemia and lung cancer.
Ascorbate oxidase levels might be altered in various cancer types.

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