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Related Experiment Videos

Ethanol and temperature modify motor axon firing patterns.

P J Stephens, R E Lazarus

    Brain Research
    |December 14, 1981
    PubMed
    Summary

    Ethanol exposure lowers the critical temperature for action potential generation in crab axons. This suggests increased membrane fluidity plays a role in peripheral spike generation.

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    Area of Science:

    • Neuroscience
    • Marine Biology
    • Physiology

    Background:

    • Action potentials in excitor (E) axons can generate additional spikes in peripheral branches at high temperatures.
    • This phenomenon is characterized by a critical temperature threshold.

    Purpose of the Study:

    • To investigate the effect of ethanol on the temperature threshold for peripheral action potential generation in crab E axons.
    • To explore the relationship between membrane lipid fluidity and peripheral spike generation.

    Main Methods:

    • Crab (Pachygrapsus crassipes) preparations were bathed in saline solutions with varying ethanol concentrations.
    • The temperature threshold for peripheral spike generation was measured.
    • The influence of acclimation temperature on the threshold was observed.

    Main Results:

    • Ethanol reversibly decreased the temperature threshold for peripheral spike generation, even at low concentrations (0.5%).
    • Higher ethanol concentrations further reduced the temperature threshold.
    • The temperature threshold was found to be dependent on the acclimation temperature.

    Conclusions:

    • Peripheral action potential generation in E axons is linked to increased membrane lipid fluidity.
    • Ethanol's effect on lowering the temperature threshold supports the role of membrane fluidity in this process.

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