Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat dopaminergic function in the retina during aging.

F Riccardi, V Covelli, P F Spano

    Neurobiology of Aging
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting.

    Infection prevention in practice·2025
    Same author

    Ten-year update of HOBOE phase III trial comparing triptorelin plus either tamoxifen or letrozole or zoledronic acid + letrozole in premenopausal hormone receptor-positive early breast cancer patients.

    ESMO open·2025
    Same author

    Final results of the real-life observational VICTOR-6 study on metronomic chemotherapy in elderly metastatic breast cancer (MBC) patients.

    Scientific reports·2023
    Same author

    [Antenatal ear examination: When, how and why?]

    Gynecologie, obstetrique, fertilite & senologie·2022
    Same author

    Metronomic chemotherapy (mCHT) in metastatic triple-negative breast cancer (TNBC) patients: results of the VICTOR-6 study.

    Breast cancer research and treatment·2021
    Same author

    T-DM1 versus pertuzumab, trastuzumab and a taxane as first-line therapy of early-relapsed HER2-positive metastatic breast cancer: an Italian multicenter observational study.

    ESMO open·2021

    Aging in rats alters retinal dopaminergic transmission. Aged rats showed higher dihydroxyphenylacetic acid (DOPAC) levels and increased binding sites for spiroperidol and methionine-enkephalin in the retina.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Gerontology

    Background:

    • Dopaminergic transmission plays a crucial role in retinal function.
    • Age-related changes in the brain's dopaminergic system are well-documented.
    • The impact of aging on the retina's dopaminergic pathways remains less understood.

    Purpose of the Study:

    • To investigate age-related alterations in dopaminergic transmission within the rat retina.
    • To compare dopaminergic parameters in mature versus aged rat retinas.
    • To examine changes in specific neurotransmitter receptor binding sites.

    Main Methods:

    • Studied dopaminergic transmission parameters in rat retinas.
    • Compared mature (3-4 months) and aged (23-24 months) rats.
    • Quantified levels of dihydroxyphenylacetic acid (DOPAC).

    Related Experiment Videos

  • Assessed binding sites for (3H-)spiroperidol and (3H)-methionine-enkephalin using radioligand binding assays.

    • Main Results:

    • Aged rats exhibited significantly higher retinal dihydroxyphenylacetic acid (DOPAC) levels compared to mature rats.
    • The number of (3H-)spiroperidol binding sites was significantly increased in the retinas of aged rats.
    • An increase in (3H)-methionine-enkephalin binding sites was also observed in senescent rat retinas.
    • These retinal changes were found to be opposite to those typically observed in the aged rat brain.

    Conclusions:

    • Aging induces significant alterations in the dopaminergic system of the rat retina.
    • The retina of aged rats shows increased dopaminergic activity and altered receptor density.
    • Observed retinal changes contrast with known brain aging patterns, suggesting unique age-related adaptations in the eye.