[A major medication for autism: sulpiride (author's transl)]

Sulpiride is a benzamide derivative used in medical practice since 1967. Its original effect became immediately apparent. It is effective against hallucinations as well as against inhibition, but is not sedative. Its antidepressant activity is still controversial. Subsequent studies confirmed the outstanding antiinhibitory effect which leads to better relationships as well as to qualitatively and quantitatively improved vigilance. Side effects, which are minor and reversible, affect the endocrine and nervous systems but do not include cholinergic effects. No drug-dependence is seen with sulpiride.