Does ethanol stimulate brain opiate receptors? Studies on receptor binding and naloxone inhibition of ethanol-induced...

The ability of ethanol to stimulate opiate receptors was investigated. Administration of ethanol 2-3.5 g/kg in rats induced analgesia as tested by the tail flick method, reduced body temperature, impaired sensorimotor performance and induced "sleep". Naloxone HCI (0.5-10 mg/kg) did not significantly attenuate these ethanol-induced behavioural changes. [3H]Etorphine binding to opiate receptors in membrane preparations from rat and mouse brains was unchanged by ethanol concentrations of 0.05-3% (v/v). It was concluded that the ethanol effects studied were not mediated by naloxone-sensitive opiate receptors.