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Related Experiment Videos

Intermittent stimulation with LH-RH in postmenopausal hypergonadotropism.

J P Hanker, U Ende, H G Bohnet

    Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
    |December 1, 1981
    PubMed
    Summary

    Postmenopausal women exhibit hyper-secretion of luteinizing hormone-releasing hormone (LH-RH). Their pituitary glands remain responsive to repeated LH-RH injections, even at high doses, maintaining a pulse-type release pattern.

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    Area of Science:

    • Reproductive Endocrinology
    • Neuroendocrinology
    • Hormone Physiology

    Background:

    • The menopausal transition is characterized by significant hormonal shifts.
    • Understanding the regulation of gonadotropin secretion in postmenopause is crucial for hormonal health.
    • Luteinizing hormone-releasing hormone (LH-RH) plays a key role in regulating the reproductive axis.

    Purpose of the Study:

    • To investigate the pituitary gland's responsiveness to repeated stimulation with luteinizing hormone-releasing hormone (LH-RH) in postmenopausal women.
    • To determine the pattern and dose-dependency of gonadotropin release following LH-RH administration in this demographic.
    • To assess whether LH-RH hyper-secretion occurs during postmenopause.

    Main Methods:

    • Ten postmenopausal women were administered eight consecutive intravenous bolus injections of either 25 or 500 micrograms of LH-RH at one-hour intervals.

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  • Gonadotropin levels (Luteinizing Hormone and Follicle-Stimulating Hormone) were monitored before and during the LH-RH stimulation period.
  • Analysis focused on the dose-dependent and sequential release patterns of LH and FSH.

    • Main Results:

    • A dose-dependent release of Luteinizing Hormone (LH) was observed after the initial LH-RH bolus.
    • Subsequent LH-RH injections consistently elicited similar LH responses, demonstrating a pulsatile release pattern.
    • The pituitary gland maintained high responsiveness to LH-RH throughout the entire stimulation period.
    • Follicle-Stimulating Hormone (FSH) release patterns were not characteristic or clearly defined in response to the stimulation.

    Conclusions:

    • Postmenopausal women appear to exhibit hyper-secretion of LH-RH.
    • The pituitary gland remains highly responsive to repeated, even supraphysiological, doses of LH-RH during postmenopause.
    • These findings suggest a persistent pituitary sensitivity to LH-RH stimulation despite menopausal hormonal changes.