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Updated: Aug 19, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
Published on: April 29, 2011
The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region
Abstract:
We have determined the nucleotide sequence of an embryonic beta-globin gene of the Balb/c mouse. It possesses structural features typical of known expressed beta-globins, including 5'-untranslated region, potential capping site, initiation and terminator codons, poly(A) addition signal, splicing signals, and intervening sequences. There is a striking 15-base homology between the putative RNA polymerase binding site of this gene and the corresponding region of a human embryonic beta-gene which may be important in the control of expression during embryonic development. The sequence of the gene predicts the sequence of the entire y2 protein, which has not previously been available. As expected from evolutionary considerations, it is more homologous to human embryonic beta-globin than to mouse adult beta-globin.
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