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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Development of the Limb Synovial Joints01:07

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Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
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Structural Joints: Synovial Joints01:16

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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Knee Joint01:23

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The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Do Younger Patients Undergoing Transfibular Total Ankle Arthroplasty Achieve Outcomes Comparable with Those of Older Patients? Interpreting Nonsignificant Differences in Clinical Research: Commentary on an article by Kevin A. Schafer, MD, et al.: "Clinical and Radiographic Outcomes at a Mean of 7 Years Following Primary Transfibular Total Ankle Arthroplasty in Younger and Older Patients".

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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
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Synovial sarcoma.

P H Wright, F H Sim, E H Soule

    The Journal of Bone and Joint Surgery. American Volume
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Synovial sarcoma patient outcomes improved after 1960, with tumor size being the most critical prognostic factor. Younger age and female sex also correlated with better survival rates in this study.

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    Area of Science:

    • Oncology
    • Orthopedic Surgery
    • Pathology

    Background:

    • Synovial sarcoma is a rare soft tissue malignancy.
    • Understanding prognostic factors is crucial for patient management.

    Purpose of the Study:

    • To analyze prognostic factors influencing survival in patients with synovial sarcoma.
    • To evaluate treatment outcomes and survival rates over time.

    Main Methods:

    • Retrospective analysis of 185 patients treated for synovial sarcoma at the Mayo Clinic.
    • Inclusion of patient demographics, tumor characteristics, treatment modalities, and survival data.
    • Regression analysis to identify significant prognostic variables.

    Main Results:

    • Overall five-year and ten-year survival rates were 38% and 23%, respectively.
    • Improved survival rates observed for patients treated since 1960 (5-year: 55%, 10-year: 38%).
    • Tumor size was the most significant prognostic factor, followed by disease extent, treatment era, age, and tumor location.

    Conclusions:

    • Prognosis for synovial sarcoma has improved, likely due to advancements in treatment.
    • Tumor size, extent of disease, and treatment era are key determinants of patient survival.
    • Female sex and younger age are associated with better outcomes.