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Rat mammary tumor classification: notes on comparative aspects.

D Komitowski, B Sass, W Laub

    Journal of the National Cancer Institute
    |January 1, 1982
    PubMed
    Summary
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    This study classified mammary tumors in rats, finding that induced tumors, particularly compound tumors and fibroadenomas, were more common than spontaneous ones. Histological analysis revealed variations in tumor types based on induction or spontaneous occurrence.

    Area of Science:

    • Veterinary Pathology
    • Oncology
    • Rattus norvegicus

    Background:

    • Mammary tumors are a significant concern in rodent models.
    • Understanding the histological classification of these neoplasms is crucial for research.

    Purpose of the Study:

    • To histologically classify spontaneous and chemically induced mammary tumors in inbred SD rats.
    • To compare the incidence of different tumor types between spontaneous and induced neoplasms.

    Main Methods:

    • Histological classification of 170 spontaneous and 1,613 induced mammary tumors in SD rats.
    • Categorization into fibroepithelial, epithelial, and connective tissue neoplasms.
    • Analysis of tumor incidence based on induction status.

    Main Results:

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    • Compound tumors were the most frequent in the fibroepithelial category, especially in induced neoplasms (63.7%).
    • Fibroadenomas and tubular adenomas were also prevalent in both spontaneous and induced groups.
    • Connective tissue tumors like fibromas and fibrosarcomas showed varying frequencies between spontaneous and induced rats.

    Conclusions:

    • Chemical induction with 7,12-dimethylbenz[a]anthracene significantly alters the prevalence of specific mammary tumor types in SD rats.
    • Histological classification provides a basis for understanding the pathogenesis of induced versus spontaneous mammary carcinogenesis.