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Related Experiment Videos

Possible ranitidine hepatitis.

G D Barr, D W Piper

    The Medical Journal of Australia
    |October 17, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Ranitidine can cause drug-induced hepatitis, a liver injury. This patient’s anicteric hepatitis resolved despite continued ranitidine use, suggesting a possible idiosyncratic drug reaction.

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    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Toxicology

    Background:

    • Drug-induced liver injury (DILI) represents a significant clinical challenge.
    • Ranitidine, a histamine H2 receptor antagonist, is widely prescribed for gastrointestinal conditions.
    • Identifying specific drug culprits in DILI can be complex due to overlapping symptoms and potential confounding factors.

    Observation:

    • A 63-year-old female patient presented with symptoms of anicteric hepatitis.
    • The onset of hepatitis occurred after two weeks of ranitidine therapy.
    • Liver enzyme levels, including transaminases and gamma-glutamyl transpeptidase, were elevated.

    Findings:

    • The patient's hepatitis was anicteric (without jaundice).
    • Hepatitis symptoms and transaminase levels normalized within weeks, despite the continuation of ranitidine therapy initially.

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  • Gamma-glutamyl transpeptidase normalized two weeks after ranitidine cessation.
  • No alternative causes for the liver injury were identified, and liver biopsy/drug rechallenge were not performed.

    • Implications:

    • This case suggests a potential idiosyncratic reaction to ranitidine causing hepatitis.
    • The resolution of symptoms despite continued drug exposure warrants further investigation into ranitidine's hepatotoxicity.
    • Clinicians should consider ranitidine as a potential cause of hepatitis, even in the absence of jaundice or with atypical recovery patterns.