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Related Experiment Videos

Coexistent multiple myeloma and primary hyperparathyroidism.

M J Stone, Z H Lieberman, Z H Chakmakjian

    JAMA
    |February 12, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    This case study highlights a patient with multiple myeloma and persistent hypercalcemia. Surgical removal of enlarged parathyroid glands normalized calcium levels, but myeloma progression led to death.

    Area of Science:

    • Endocrinology
    • Oncology
    • Nephrology

    Background:

    • Multiple myeloma can cause hypercalcemia, often associated with bone lesions.
    • Persistent hypercalcemia in myeloma patients warrants investigation for other causes.
    • Primary hyperparathyroidism is a potential, though less common, cause of hypercalcemia.

    Observation:

    • A patient with multiple myeloma and hypercalcemia refractory to chemotherapy was evaluated.
    • Absence of lytic bone lesions and low serum phosphate suggested alternative diagnoses.
    • Family history hinted at possible primary hyperparathyroidism.

    Findings:

    • Elevated serum parathyroid hormone and urinary cyclic adenosine monophosphate confirmed primary hyperparathyroidism.
    • Surgical excision of significantly enlarged parathyroid glands (1,850 mg and 210 mg) was performed.

    Related Experiment Videos

  • Post-surgery, serum calcium levels normalized for one year.

    • Implications:

    • This case underscores the importance of considering and evaluating for primary hyperparathyroidism in myeloma patients with persistent hypercalcemia.
    • Accurate diagnosis and management of concurrent endocrine disorders are crucial for patient outcomes.
    • While parathyroidectomy can resolve hypercalcemia, underlying myeloma progression remains a critical factor in patient prognosis.