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Diagnosis and treatment of allograft rejection
Several immunologic tests hve been developed to predict allograft rejection prior to functional renal impairment. Unfortunately, no test has as yet proven unequivocally to be of clinical value. Serial serum creatinine determinations and 131I hippuran scintiphotography have proven to be the most useful tests in detecting rejection episodes. Treatment of an acute rejection episode is often successful, but chronic rejection causes a slowly progressive deterioration of allograft function and is unresponsive to treatment.
Several immunologic tests hve been developed to predict allograft rejection prior to functional renal impairment. Unfortunately, no test has as yet proven unequivocally to be of clinical value. Serial serum creatinine determinations and 131I hippuran scintiphotography have proven to be the most useful tests in detecting rejection episodes. Treatment of an acute rejection episode is often successful, but chronic rejection causes a slowly progressive deterioration of allograft function and is unresponsive to treatment.