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Ranitidine heals duodenal ulcers.

I N Marks, J P Wright, M Denyer

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |January 30, 1982
    PubMed
    Summary
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    Ranitidine significantly improved duodenal ulcer healing rates compared to placebo in a double-blind study. This ranitidine therapy demonstrated safety and effectiveness for duodenal ulceration.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Duodenal ulceration is a common gastrointestinal condition.
    • Effective and safe treatment options are crucial for patient outcomes.

    Purpose of the Study:

    • To evaluate the efficacy and safety of ranitidine in treating duodenal ulceration.
    • To compare ranitidine's healing rates against a placebo control.

    Main Methods:

    • A double-blind, placebo-controlled study involving 80 patients with endoscopically confirmed duodenal ulcers.
    • Patients received either ranitidine 150 mg twice daily or a placebo for 4 weeks.
    • Ulcer healing was assessed endoscopically.

    Main Results:

    • Ranitidine achieved endoscopic healing in 82% of patients, significantly higher than the 45% in the placebo group (P < 0.005).

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  • Patients with unhealed ulcers after initial treatment showed high healing rates (80-86%) upon receiving further ranitidine therapy.
  • No significant adverse reactions were observed in either treatment group.

    • Conclusions:

    • Ranitidine is a safe and effective treatment for duodenal ulceration.
    • Initial non-response to placebo did not preclude subsequent successful treatment with ranitidine.