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Allergic Reactions

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Updated: Jun 30, 2026

Quantitative Autonomic Testing

Quantitative Autonomic Testing

Published on: July 19, 2011

Autonomic nervous system abnormalities and allergy.

M Kaliner, J H Shelhamer, P B Davis

Annals of Internal Medicine

|March 1, 1982

Summary

This summary is machine-generated.

Allergic diseases involve abnormal autonomic nervous system responses. Allergic asthma shows unique alpha-adrenergic hyperresponsiveness, while all allergic individuals exhibit beta-adrenergic hyporeactivity and cholinergic hypersensitivity.

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Area of Science:

Immunology
Autonomic Nervous System Physiology
Allergic Diseases

Background:

Autonomic nervous system (ANS) dysfunction is implicated in the development of asthma and allergic conditions.
Understanding adrenergic and cholinergic receptor function is crucial for elucidating allergic disease pathogenesis.

Purpose of the Study:

To investigate alpha- and beta-adrenergic and cholinergic responsiveness in individuals with allergic diseases.
To identify specific ANS abnormalities associated with allergic asthma, allergic rhinitis, and pre-allergic states.

Main Methods:

Measurement of alpha-adrenergic, beta-adrenergic, and cholinergic responsiveness in allergic subjects.
Assessment of autoantibodies against beta-receptors.

Main Results:

Allergic asthmatic subjects displayed hyperresponsiveness to alpha-adrenergic and cholinergic stimuli, and hyporesponsiveness to beta-adrenergic stimuli.
Subjects with allergic rhinitis and pre-allergic individuals showed similar beta-adrenergic hyporeactivity and cholinergic hypersensitivity.
Allergic asthma was uniquely linked to excessive alpha-adrenergic responsiveness.
Autoantibodies against beta-receptors were more prevalent in subjects with beta-adrenergic hyporeactivity, suggesting a potential causal role.

Conclusions:

Allergic individuals exhibit a common pattern of beta-adrenergic hyporeactivity and cholinergic hypersensitivity.
Excessive alpha-adrenergic responsiveness is a distinguishing feature of allergic asthma.
The presence of autoantibodies against beta-receptors may contribute to the observed beta-adrenergic hyporeactivity in allergic conditions.