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Teratology study of intravaginally administered nonoxynol-9-containing contraceptive cream in rats
Fertility and Sterility
|January 1, 1982
Abstract:
Pregnant Long-Evans Hooded rats were intravaginally administered nonoxynol-9, a non-ionic surfactant used as a spermicidal agent in Delfen Contraceptive Cream (Ortho Pharmaceutical Corporation, Raritan, N.J.) at dosages of 4 or 40 mg/kg/day (2 and 20 times the clinical usage) on days 6 through 15 of gestation. Untreated, vehicle and sham control groups were also incorporated into the study protocol. No meaningful differences were observed between the treated and control groups in maternal toxicity, gross and microscopic appearance of vagina, maternal reproductive parameters, fetal toxicity, and the incidence of visceral and skeletal malformations.
Keywords:
AlcoholsAnimals, LaboratoryBiologyBody WeightClinical ResearchCongenital AbnormalitiesContraceptionContraceptive AgentsContraceptive Methods--administraction and dosageDiseasesFamily PlanningIncidenceIngredients And ChemicalsMeasurementNeonatal Diseases And AbnormalitiesNonoxynol--administraction and dosageOrganic ChemicalsPhysiologyResearch MethodologySpermicidal Contraceptive AgentsVaginal Cream--administraction and dosageVaginal Spermicides--administraction and dosage