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Lung cancer in young persons.

L DeCaro, J R Benfield

    The Journal of Thoracic and Cardiovascular Surgery
    |March 1, 1982
    PubMed
    Summary

    Lung cancer is rare in individuals under 40 but often aggressive. Early, aggressive surgical treatment, even for advanced lung cancer, can improve survival rates in young patients.

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    Area of Science:

    • Oncology
    • Thoracic Surgery
    • Pulmonary Medicine

    Background:

    • Lung cancer in patients under 40 years old is a rare occurrence.
    • A study analyzed 718 lung cancer patients, identifying 35 (5%) under 40, predominantly heavy smokers.

    Purpose of the Study:

    • To investigate the characteristics, treatment outcomes, and survival rates of lung cancer in young patients (under 40).
    • To compare the prognosis of young lung cancer patients with older counterparts.

    Main Methods:

    • Retrospective analysis of 718 lung cancer patients, focusing on a subgroup of 35 patients under 40.
    • Comparison of survival data between young operated and non-operated patients, and between young operated patients and older operated patients.
    • Analysis of histological types, including adenocarcinoma and small cell undifferentiated carcinoma, in the young patient cohort.

    Main Results:

    • Young operated patients (12) survived 41.7 months (SD 46.3), with Stage 3 patients surviving 19.2 months (SD 16.0) and node-negative patients surviving over 3 years.
    • Non-operated young patients (23) had a significantly shorter survival of 5.6 months (SD 3.1) compared to older non-operated patients (p < 0.0001).
    • The 5-year survival rate for young operated patients was comparable to older operated patients; however, young patients presented with a higher incidence of adenocarcinoma and small cell undifferentiated carcinoma.

    Conclusions:

    • Lung cancer in young individuals is often virulent, with frequently delayed diagnoses.
    • Aggressive surgical resection, even for advanced local disease, is recommended for selected young patients.
    • This patient group warrants innovative, intensive efforts for prompt diagnosis and experimental multimodal therapy.

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