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Radiation-induced osteochondromas.

H I Libshitz, M A Cohen

    Radiology
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Radiation therapy for childhood cancers can lead to radiation-induced osteochondromas in about 12% of cases. These benign bone tumors typically affect growing bone and rarely become malignant.

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    Area of Science:

    • Orthopedic Oncology
    • Pediatric Radiology
    • Radiation Oncology

    Background:

    • Radiation-induced osteochondromas are a recognized but often underestimated complication.
    • The incidence following irradiation for pediatric malignancies is approximately 12%.

    Purpose of the Study:

    • To discuss the incidence, clinical presentation, and management of radiation-induced osteochondromas.
    • To highlight the vulnerability of open epiphyses to radiation-induced bone tumors.

    Main Methods:

    • Review of 14 cases of radiation-induced osteochondromas.
    • Analysis of factors including age at irradiation, time to appearance, radiation dose and type, and clinical course.

    Main Results:

    • Osteochondromas developed in approximately 12% of patients treated for childhood malignancy.

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  • Any open epiphysis was found to be vulnerable.
  • Three tumors were surgically excised due to growth or pain, with no evidence of malignant transformation.

    • Conclusions:

    • Radiation-induced osteochondromas are a significant concern following pediatric cancer treatment.
    • These lesions, while typically benign, require monitoring and may necessitate surgical intervention.
    • Malignant degeneration was not observed in the discussed cases.