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[Sarcoidosis and hyperthyroidism (author's transl)].

J Taillandier, N Faux, G Manigand

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |March 11, 1982
    PubMed
    Summary
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    Thyrotoxicosis can develop after stopping corticosteroid treatment for sarcoidosis. Reinstating corticosteroids often reverses these hyperthyroid symptoms, highlighting the link between the conditions.

    Area of Science:

    • Endocrinology
    • Immunology
    • Pulmonology

    Background:

    • Sarcoidosis is a multisystem inflammatory disease.
    • Corticosteroids are a common treatment for sarcoidosis.
    • Thyrotoxicosis is a condition of excess thyroid hormones.

    Observation:

    • A 31-year-old man developed thyrotoxicosis four months after discontinuing long-term corticosteroid therapy for sarcoidosis.
    • The patient's thyrotoxicosis symptoms and biological markers improved upon reinitiating corticosteroid treatment.

    Findings:

    • Hyperthyroidism associated with sarcoidosis predominantly affects females.
    • Hyperthyroidism typically occurs secondary to sarcoidosis onset.
    • Concurrent treatment of both sarcoidosis and hyperthyroidism is often necessary.

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  • Corticosteroid therapy alone may not be sufficient to manage both conditions.

    • Implications:

    • This case and literature review underscore the complex interplay between sarcoidosis and thyroid dysfunction.
    • Physicians should consider thyrotoxicosis in patients with sarcoidosis, especially after corticosteroid withdrawal.
    • Simultaneous management strategies are crucial for patients with co-existing sarcoidosis and hyperthyroidism.