Related Experiment Video
Updated: Aug 19, 2026

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
Published on: May 25, 2011
The action of putative neurotransmitter substances in the cat labyrinth
Abstract:
Possible neurotransmitter candidates were tested in the labyrinth of the cat with the aid of microiontophoretic techniques. Depending on the recording site, spontaneous regular or irregular fibre activity was obtained in the subsynaptic region of the macula sacculi. Ejection of GABA enhances the firing rate, whereas acetylcholine reduces the spontaneous activity. A similar application of glycine and proline produced no effect. The action of GABA was specifically blocked by the GABA antagonists bicuculline and picrotoxin. The alkaloids further induced a decrease in the spontaneous activity which lasted for several minutes.
Related Concept Videos
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Neurochemical Transmission: Sites of Drug Action
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

