Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[GH after baclofen and diazepam].

P Carletti, P P Morosini, G F Ferretti

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |December 15, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Translation and validation of the Visual Function and Corneal Health Status (V-FUCHS) questionnaire into Spanish language.

    Archivos de la Sociedad Espanola de Oftalmologia·2023
    Same author

    Chemical and biological characterization of dissolved organic matter from silver fir and beech forest soils.

    Chemosphere·2006
    Same author

    Infectious diseases and natural disasters: the effects of Hurricane Mitch over Villanueva municipal area, Nicaragua.

    Public health reviews·2000
    Same author

    [Evaluation of the workload resulting from iatrogenic pathology in a medical ward in a regional hospital].

    Recenti progressi in medicina·2000
    Same author

    [The probability of assessing the pathogenesis of ischemic stroke. Study of 81 patients].

    Recenti progressi in medicina·2000
    Same author

    Paraneoplastic syndromes in 68 cases of resectable non-small cell lung carcinoma: can they help in early detection?

    Medical oncology (Northwood, London, England)·1999

    Benzodiazepines prolong the growth hormone (GH) releasing effects of Baclofen, a GABAergic drug. This suggests a combined action at the hypothalamo-hypophyseal level in humans.

    Area of Science:

    • Neuroendocrinology
    • Pharmacology

    Context:

    • GABAergic receptors have distinct binding sites for GABA and benzodiazepines.
    • GABA receptor activation opens chloride channels, enhanced by simultaneous agonist binding.
    • Baclofen, a GABAergic drug, acutely increases serum growth hormone (GH) in humans.

    Purpose:

    • To investigate if benzodiazepines potentiate the growth hormone (GH) secretion effect of Baclofen in vivo.
    • To explore the interaction between GABA and benzodiazepine pathways on hypothalamo-hypophyseal function.

    Summary:

    • Five healthy women received oral Baclofen (20 mg), with serum GH levels monitored over 210 minutes.
    • The same test was repeated one week later, with participants pre-medicated with oral Diazepam (12 mg).
    • Results indicated that Diazepam premedication prolonged the Baclofen-induced increase in serum GH.

    Related Experiment Videos

    Impact:

    • The findings suggest a synergistic interaction between GABA and benzodiazepine pathways at the hypothalamo-hypophyseal level in humans.
    • This interaction influences growth hormone (GH) secretion, offering insights into neuroendocrine regulation.