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Clonidine and glucose intolerance.

W B Webster, M M McConnaughey

    Drug Intelligence & Clinical Pharmacy
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Clonidine, a medication for hypertension, can worsen blood sugar control in diabetic patients. This is likely due to clonidine

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    Area of Science:

    • Endocrinology
    • Pharmacology
    • Cardiovascular Medicine

    Background:

    • Clonidine is a medication commonly used to manage hypertension.
    • Diabetes mellitus and hypertension often coexist, requiring careful medication management.
    • Carbohydrate metabolism is a critical factor in diabetes control.

    Observation:

    • A patient with diabetes and hypertension experienced worsened blood sugar control with clonidine treatment.
    • Increasing the clonidine dose led to further deterioration of glucose control.
    • Discontinuation of clonidine resulted in the resolution of glucose intolerance.

    Findings:

    • Radioligand binding studies revealed a predominant presence of alpha 2-adrenergic receptors in animal pancreatic tissue.
    • The observed clinical response suggests clonidine's action on these pancreatic alpha 2-receptors.

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  • This indicates a potential mechanism for clonidine-induced glucose intolerance.

    • Implications:

    • Clonidine may adversely affect glucose metabolism through specific interactions with pancreatic alpha 2-receptors.
    • Clinicians should monitor carbohydrate metabolism in diabetic patients treated with clonidine.
    • Further research is warranted to elucidate the precise mechanisms and clinical significance.