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[Eosinophilic meningomyelitis (author's transl)].

H G Hoffmann, H W Kölmel, M Alexander

    Infection
    |January 1, 1982
    PubMed
    Summary

    Central nervous system infections can cause significant cerebrospinal fluid (CSF) eosinophilia. This pronounced eosinophil elevation in CSF is typically short-lived in non-parasitic cases.

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    Area of Science:

    • Neurology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Acute meningomyelitis is a severe neurological condition affecting the spinal cord and meninges.
    • Cerebrospinal fluid (CSF) analysis is crucial for diagnosing central nervous system (CNS) disorders.
    • Eosinophilia in CSF is often associated with parasitic infections, but its role in other CNS conditions is less understood.

    Observation:

    • A patient presented with acute meningomyelitis and paraplegia, exhibiting over 50% eosinophils in their CSF for ten days.
    • Serological tests indicated a concurrent infection with Mycoplasma pneumoniae and Coxsackie A 09 as the probable cause.

    Findings:

    • This case highlights that significant CSF eosinophilia can occur transiently in non-parasitic CNS infections.
    • The observed eosinophilia resolved within ten days, differentiating it from the prolonged eosinophilia seen in parasitic infestations.

    Implications:

    • The findings challenge the assumption that CSF eosinophilia exclusively indicates parasitic infections.
    • Clinicians should consider non-parasitic etiologies, such as viral or bacterial infections, in cases of acute CNS inflammation with eosinophilic CSF.
    • Differentiating between parasitic and non-parasitic causes of eosinophilia relies on the duration of the elevation.

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