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[Clinical experience with ceftizoxime in the pediatric field (author's transl)]
Insights
Ceftizoxime (CZX) is an effective intravenous antibiotic for treating various pediatric bacterial infections, showing good clinical and bacteriological responses in most cases. Side effects were minimal, indicating its utility in pediatric care.
Area of Science:
- Pediatric Infectious Diseases
- Bacteriology
- Pharmacology
Context:
- Acute bacterial infections in children require effective antibiotic treatment.
- Ceftizoxime (CZX) is a third-generation cephalosporin antibiotic.
- Assessing the efficacy and safety of CZX in pediatric patients is crucial.
Purpose:
- To evaluate the clinical and bacteriological effectiveness of intravenous Ceftizoxime (CZX) in children.
- To document the range of acute bacterial infections treated with CZX.
- To identify and report any adverse effects associated with CZX therapy.
Summary:
- Intravenous Ceftizoxime (CZX) was administered to 28 children with diverse acute bacterial infections, including bronchopneumonia, urinary tract infections, and meningitis.
- Good clinical responses were observed in 26 out of 28 patients, with bacteriological effectiveness confirmed in all 14 cases evaluated.
- Adverse effects were infrequent, with only two cases reporting drug fever and eosinophilia, respectively.
Impact:
- Ceftizoxime (CZX) demonstrates significant utility as an antibiotic for treating a spectrum of bacterial infections in pediatric patients.
- The study supports the use of CZX in clinical practice for managing pediatric bacterial infections.
- Minimal side effects suggest a favorable safety profile for CZX in children.
Abstract:
Ceftizoxime (CZX) was given intravenously to 28 children with the following acute bacterial infections; 15 cases of bronchopneumonia, 4 cases of urinary tract infection, 3 cases of purulent meningitis, 2 cases of acute tonsillitis, each 1 case of purulent cervical lymphadenitis and acute tonsillitis, orbital cellulitis, abscess of eyelid, and peritonitis. Out of 28 patients, good clinical responses were obtained in 26 patients, and bacteriological effectiveness was seen in all 14 cases. Side effects with CZX were observed in 2 cases; 1 case was drug fever, and the other case was eosinophilia. From the above clinical results, CZX is useful antibiotic for treating the pediatric patients with various kinds of bacterial infections.