Related Experiment Video

Updated: Aug 17, 2026

Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
10:47

Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice

Published on: April 14, 2011

[Haemophilus influenza infections in infants and mothers. Three cases (author's transl)]

G Pinon, R Quentin, G Boscq

    La Nouvelle Presse Medicale
    |March 20, 1982
    PubMed

    Insights

    Early detection and treatment of Haemophilus influenzae (H. influenzae) perinatal infections are crucial. Cefotaxime shows promise as an alternative antibiotic for resistant strains, preventing serious neonatal complications.

    Area of Science:

    • Neonatal infections
    • Microbiology
    • Infectious diseases

    Background:

    • Haemophilus influenzae (H. influenzae) can cause serious perinatal infections in newborns.
    • Some H. influenzae strains are resistant to common penicillin treatments due to beta-lactamase production.
    • Prompt diagnosis and effective treatment are vital to prevent severe neonatal complications.

    Purpose of the Study:

    • To report on three cases of H. influenzae perinatal infections.
    • To evaluate antibiotic susceptibility, including resistance to penicillins.
    • To identify alternative treatment options for H. influenzae neonatal infections.

    Main Methods:

    • Diagnosis via direct examination and culture of placental tissue, gastric fluid, and peripheral specimens at birth.
    • Use of chocolate agar medium for optimal H. influenzae growth.
    • Antibiotic susceptibility testing, including Minimum Inhibitory Concentrations (MICs) for eight antibiotics.

    Main Results:

    • One isolate demonstrated beta-lactamase production, conferring resistance to group A penicillins.
    • MICs indicated cefotaxime as a suitable alternative to penicillins against resistant H. influenzae strains.
    • Published cases include meningitis, septicaemia, and arthritis associated with H. influenzae.

    Conclusions:

    • Early detection of H. influenzae perinatal infections enables timely treatment.
    • Cefotaxime presents a viable therapeutic option for penicillin-resistant H. influenzae neonatal infections.
    • Effective management can prevent the development of severe complications in neonates.

    More Related Videos

    Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation09:56

    Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

    Published on: March 2, 2016

    Assessing Respiratory Immune Responses to Haemophilus Influenzae06:32

    Assessing Respiratory Immune Responses to Haemophilus Influenzae

    Published on: June 29, 2021

    Related Concept Videos

    Development of Immunocompetence01:22

    Development of Immunocompetence

    The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
    The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
    Subsequent T...
    Sexually Transmitted Infections01:26

    Sexually Transmitted Infections

    Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
    Bacterial Meningitis01:24

    Bacterial Meningitis

    Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
    Viral Meningitis01:18

    Viral Meningitis

    Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
    Influenza01:27

    Influenza

    Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
    Bacterial Meningitis I: Introduction01:22

    Bacterial Meningitis I: Introduction

    Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...