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Related Experiment Videos

Opiate antagonists stimulate affiliative behaviour in monkeys.

C Fabre-Nys, R E Meller, E B Keverne

    Pharmacology, Biochemistry, and Behavior
    |April 1, 1982
    PubMed
    Summary

    Opiate receptor blockade with naltrexone and naloxone increased grooming behaviors in talapoin monkeys. These drugs also elevated luteinizing hormone (LH), testosterone, and cortisol levels, suggesting endorphin involvement in social bonding.

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    Area of Science:

    • Neuroscience
    • Primate Behavior
    • Endocrinology

    Background:

    • Social behavior and endocrine responses are crucial in primate interactions.
    • Endogenous opioid systems are implicated in regulating affect and social bonding.

    Purpose of the Study:

    • To investigate the effects of opiate receptor antagonists (naltrexone, naloxone) and a dopamine antagonist (sulpiride) on the behavior and endocrine profiles of talapoin monkeys.
    • To explore the role of endorphins in mediating social behaviors and affective states in primates.

    Main Methods:

    • Talapoin monkeys were treated with naltrexone hydrochloride, naloxone hydrochloride, or sulpiride via intramuscular injections.
    • Behavioral observations (grooming, aggression, locomotion) and endocrine measurements (LH, testosterone, cortisol, prolactin) were conducted before, during, and after drug administration.

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  • Animals were studied in social pairs and individually housed.

    • Main Results:

    • Naltrexone and naloxone significantly increased grooming and grooming invitations, while sulpiride had no effect on these behaviors.
    • Aggressive behavior, self-grooming, scratching, and general locomotor activity remained unaffected by the treatments.
    • Opiate receptor blockade led to increased plasma levels of luteinizing hormone (LH), testosterone, and cortisol.
    • Prolactin levels were unchanged by naltrexone and naloxone but increased significantly with sulpiride treatment.
    • No endocrine changes preceded the observed increase in grooming behavior induced by opiate receptor blockade.

    Conclusions:

    • The findings support the hypothesis that endorphin-containing systems mediate positive affect associated with social bonds in primates.
    • Opiate receptor antagonists can modulate social grooming behaviors and influence key hormones involved in stress and reproduction.
    • Cerebral endorphin systems play a significant role in the neurobiological underpinnings of primate social interactions and emotional states.