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Herpes simplex vaccine using cell membrane associated antigen in an animal model

B Thornton, J B Griffiths, A Walkland

    Developments in Biological Standardization
    |January 1, 1981
    PubMed

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    Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...