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Stress reactions and endorphinergic systems.

H M Emrich, M J Millan

    Journal of Psychosomatic Research
    |January 1, 1982
    PubMed
    Summary

    Endorphins, the body's natural opiates, are key regulators of pain and bodily functions. Research explores their role in stress responses across various studies in animals and humans.

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    Area of Science:

    • Neuroscience
    • Psychopharmacology
    • Pain Research

    Background:

    • Endorphins are endogenous peptides with opiate-like activity.
    • They play a crucial role in regulating pain and vegetative functions.
    • Their involvement in stress phenomena is an area of active investigation.

    Purpose of the Study:

    • To investigate the role of endorphins in stress phenomena.
    • To summarize the current state of research on endorphins and stress.

    Main Methods:

    • Measuring endorphin concentrations and release in brain regions.
    • Assessing animal pain sensitivity and behavior before/after stress, with/without naloxone.
    • Measuring endorphin levels in cerebrospinal fluid (CSF) and plasma of patients with neuroses and psychoses.

    Main Results:

    • Studies utilized diverse strategies to explore endorphin function under stress.
    • Animal models and human patient data were analyzed.
    • The research synthesized findings from various experimental approaches.

    Conclusions:

    • Endorphins are implicated in the body's response to stress.
    • Further research is needed to fully elucidate their complex role.
    • This summary provides an overview of the current understanding in the field.

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