Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[ACTH response in the dexamethasone suppression test].

E Jungmann, F Schulz, W Magnet

    Medizinische Klinik (Klinik-Ausg.)
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical management of CMML-State of the art.

    British journal of haematology·2025
    Same author

    Refinement of intermediate-risk Karyotypes according to the IPSS-R in patients with myelodysplastic neoplasms (MDS).

    Annals of hematology·2025
    Same author

    Incorporation strategy for organic dyes into gold nanoparticle supercrystals.

    The Journal of chemical physics·2024
    Same author

    The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification.

    Leukemia·2024
    Same author

    Measurement of the α-Particle Monopole Transition Form Factor Challenges Theory: A Low-Energy Puzzle for Nuclear Forces?

    Physical review letters·2023
    Same author

    The impact of accuracy and precision of analytical test methods on the determination of withdrawal periods.

    Critical reviews in toxicology·2023
    Same journal

    [New culture method for the diagnosis of bacteriurias].

    Medizinische Klinik (Klinik-Ausg.)·1982
    Same journal

    [Bacterial hospital infections are dependent on policy regarding administration of antibiotics and hospital hygiene].

    Medizinische Klinik (Klinik-Ausg.)·1982
    Same journal

    [What is your diagnosis? Schistosomiasis (Schistosoma mansoni)].

    Medizinische Klinik (Klinik-Ausg.)·1982
    Same journal

    [New data on body height].

    Medizinische Klinik (Klinik-Ausg.)·1982
    Same journal

    [Late manifestations of glycogenosis 1 in early adulthood].

    Medizinische Klinik (Klinik-Ausg.)·1982
    Same journal

    [Nutrition of critically ill patients].

    Medizinische Klinik (Klinik-Ausg.)·1982
    See all related articles

    Dexamethasone suppresses cortisol rhythm but not morning ACTH levels in normal subjects. Basal ACTH is biologically inactive and resistant to suppression, suggesting its measurement is best during stimulation tests for hypercortisolism diagnosis.

    Area of Science:

    • Endocrinology
    • Hormone Regulation
    • Clinical Diagnostics

    Context:

    • The low-dose dexamethasone suppression test and plasma ACTH measurement are clinically vital.
    • Limited understanding exists regarding ACTH response to dexamethasone in healthy individuals.

    Purpose:

    • To investigate the ACTH response to dexamethasone in normal subjects.
    • To assess cortisol response to ACTH under dexamethasone influence.

    Summary:

    • Morning ACTH concentrations exhibit periodicity similar to cortisol's circadian rhythm.
    • Dexamethasone disrupts cortisol periodicity without significantly reducing ACTH.
    • Cortisol response to ACTH remains normal post-dexamethasone, indicating secretion of basal, inactive ACTH.

    Related Experiment Videos

    Impact:

    • Findings suggest morning ACTH is basal and biologically inactive, resistant to dexamethasone suppression.
    • Recommends measuring ACTH during stimulation tests (e.g., insulin-induced hypoglycemia) for accurate hypercortisolism diagnosis.