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Pathological correlation of CT ring in recurrent, previously treated gliomas
Surgical Neurology
|April 1, 1982
Summary
The enhancing ring in treated glioblastoma CT scans often indicates viable tumor, not just radiation effects. Monitoring ring volume and enhancement on scans may predict treatment failure.
Area of Science:
- Neuro-oncology
- Radiology
- Pathology
Background:
- The enhancing ring on CT scans of recurrent glioblastoma is ambiguous.
- Differential diagnoses include radiation necrosis, pseudocapsule, compressed brain, or viable tumor.
Purpose of the Study:
- To determine the pathological nature of the enhancing ring in recurrent glioblastoma.
- To correlate imaging findings with tumor recurrence.
Main Methods:
- Multiple intratumoral biopsies were performed during reoperation.
- Histopathological analysis of biopsy samples was conducted.
Main Results:
- Pathological evidence confirmed the enhancing ring represents viable tumor tissue.
- The ring's content was definitively identified as active glioblastoma.
Conclusions:
- The enhancing ring in treated glioblastoma signifies tumor recurrence.
- Sequential CT scan analysis of ring volume and enhancement can help assess treatment failure.