Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Plasma digoxin concentration in different age groups (author's transl)].

D Lang, R Hofstetter, G von Bernuth

    Klinische Wochenschrift
    |January 15, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Micropattern platform promotes extracellular matrix remodeling by human PSC-derived cardiac fibroblasts and enhances contractility of co-cultured cardiomyocytes.

    Physiological reports·2021
    Same author

    Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts.

    Biotechnology and bioengineering·2020
    Same author

    A repeating fast radio burst source localized to a nearby spiral galaxy.

    Nature·2020
    Same author

    Association between antibiotics use and outcome in patients with NSCLC treated with immunotherapeutics.

    Annals of oncology : official journal of the European Society for Medical Oncology·2019
    Same author

    The transcriptional landscape of polyploid wheat.

    Science (New York, N.Y.)·2018
    Same author

    Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation.

    BMC molecular biology·2015

    Newborns have higher plasma digoxin concentrations than adults due to age-related differences in dose, distribution, and excretion. Premature newborns showed even higher levels compared to infants and children.

    Area of Science:

    • Pharmacokinetics
    • Pediatric Pharmacology
    • Neonatal Medicine

    Context:

    • Digoxin is a critical medication for treating heart conditions in various age groups.
    • Understanding age-specific plasma digoxin concentrations is vital for safe and effective therapeutic drug monitoring.
    • Previous research has indicated potential pharmacokinetic variations across pediatric populations.

    Purpose:

    • To determine and compare plasma digoxin concentrations in premature newborns, mature newborns, infants, children, and adults receiving maintenance digoxin therapy.
    • To investigate the influence of age on digoxin pharmacokinetics, including dose, volume of distribution, and excretion rate.

    Summary:

    • Plasma digoxin concentrations were significantly higher in newborns compared to adults.

    Related Experiment Videos

  • Premature newborns exhibited the highest plasma digoxin concentrations among all studied age groups.
  • Observed differences are attributed to variations in digoxin dose, volume of distribution, and excretion rates across different age demographics.

    • Impact:

    • Provides crucial data for optimizing digoxin dosing strategies in pediatric and neonatal populations.
    • Highlights the need for age-specific therapeutic drug monitoring guidelines for digoxin.
    • Informs clinical practice regarding the safe and effective use of digoxin in neonates and children.