[Histological, morphometric and topochemical analysis of placentas from pregnancies with EPH Gestosis (author's...

The authors' studies have shown three pathological phenomena to be predominant in placentas of women with EPH gestosis: disappearance of acid mucosubstance from wall of spiral arteries, reduction of ATPase, 5-Nase, and aP activities on apical and basal surfaces of terminal villi, and numerical increase as well as de-differentiation of trophoblastic nodes. Vulnerability of vascular walls to the action of vasodepressive factors is aggravated, according to the authors, in cases of complicated gestosis in which aMPS levels in the muscular membranes of spiral arteries are inadequate.