Related Experiment Video
Updated: Oct 13, 2026

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Published on: July 4, 2016
Spin label electron paramagnetic resonance (EPR) studies of Huntington disease erythrocyte membranes
Abstract:
Several spin-label electron paramagnetic resonance (EPR) studies of red cell membranes appear to show abnormalities in some Huntington disease (HD) patients, but not in others. Both studies measure the W/S ratios, presumably under similar conditions, but have different results. We have studied the W/S ratio in some detail to gain a better understanding of this experimental parameter and to determine its potential application in detecting HD abnormalities. Our results offer little encouragement for continued use of W/S as an indication of membrane defect in HD.
Related Concept Videos
Electron Paramagnetic Resonance (EPR) Spectroscopy: Organic Radicals
Huntington Disease l: Introduction

