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[The production of superoxide anion (O2-) by polymorphonuclear cells in patients with rheumatoid arthritis]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|April 15, 1982
Abstract:
Superoxide anion production has been determined in controls and RA patients PMNs stimulated with zymosan, rheumatoid synovial membrane, nodule and synovial fluid, rheumatoid factor, aggregated gamma-globulins, Mycoplasma and Epstein-Barr virus. Patients with RA showed an increased production of O2- after incubation with zymosan and rheumatoid tissue extracts or synovial fluid in comparison to normal controls. The findings indicate that rheumatoid PMNs become activated by different stimuli to produce an excess of O2- which can contribute to chronic inflammatory process.
Insights
Rheumatoid arthritis patients
Area of Science:
- Immunology
- Biochemistry
Context:
- Rheumatoid arthritis (RA) is a chronic inflammatory disease.
- Polymorphonuclear neutrophils (PMNs) play a role in RA pathogenesis.
Purpose:
- To investigate superoxide anion (O2-) production in PMNs from RA patients.
- To compare O2- production in RA PMNs versus healthy controls when stimulated by various agents.
Summary:
- RA patients' PMNs exhibited elevated O2- production when stimulated with zymosan, rheumatoid tissue extracts, or synovial fluid compared to controls.
- This increased O2- production by activated rheumatoid PMNs suggests a contribution to the chronic inflammatory process in RA.
Impact:
- Findings suggest that activated rheumatoid PMNs contribute to RA's chronic inflammation.
- Highlights potential therapeutic targets related to O2- production in RA.