Related Experiment Videos
[Treatment of Wilms' tumor (author's transl)]
Insights
This study on Wilms' tumor treatment in Austria found a 90.6% survival rate in children following the National Wilms' Tumor Study protocols. Early diagnosis and adequate treatment are crucial for successful Wilms' tumor outcomes.
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Radiation Oncology
Context:
- Implementation of the 1st and 2nd US National Wilms' Tumor Study treatment protocols in Austria.
- Diagnosis of 34 children with Wilms' tumor between January 1976 and February 1980.
- Multidisciplinary approach involving pediatricians, surgeons, urologists, and radiotherapists.
Purpose:
- To evaluate the efficacy of a uniform treatment strategy for Wilms' tumor based on established US national studies.
- To assess survival rates and treatment outcomes in a cohort of Austrian children diagnosed with Wilms' tumor.
Summary:
- A total of 34 children were diagnosed with Wilms' tumor (stages I-IV).
- Of 32 children who received treatment, 29 (90.6%) are alive with long-term survival.
- Tumor-free survival rate was 74.2%, with 21 children requiring no further treatment. Recurrences were noted in 5 children, with two surviving long-term despite lung metastases.
Impact:
- Demonstrates the successful application of standardized national treatment protocols in an international setting.
- Highlights the importance of adequate initial treatment to prevent recurrence and improve survival rates for pediatric Wilms' tumor patients.
- Provides evidence for high survival rates and long-term outcomes in Wilms' tumor management.
Abstract:
Uniform treatment based on the therapeutic approach of the 1st and 2nd US National Wilms' Tumor Study was decided on in March 1976 by paediatricians, surgeons, urologists and radiotherapists in Austria. Wilms' tumour was diagnosed in 34 children between 1 january 1976 an 29 february 1980 (stage I: n = 11, stage II: n = 8, stage III: n = 8, stage IV: n = 7). Parents of two children refused treatments; both children have since died of metastases. Of the remaining 32 children 29 (90.6%) are alive, 10 for more than 4, 15 for more than 3 and 19 for more than 2 years after diagnosis. 21 children are without need of treatment. Three children have died, one due to postoperative complications, one due to haemorrhagic chickenpox, but free of tumour, and one after insufficient treatment. Two of the five children with a recurrence between 2 1/4 to 15 months after diagnosis had been treated inadequately in the initial phase. The tumour free survival rate in 74.2%. Two children with early occurring or recurrent lung metastases have survived for 53 1/2 and 54 months up to now.