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[Low-symptom herpes simplex encephalitis (author's transl)].

E Finke, R Ackermann, K Felgenhauer

    Deutsche Medizinische Wochenschrift (1946)
    |July 2, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    This case study highlights a rare survival of herpes simplex encephalitis, a severe brain infection, with minimal neurological impact. Early diagnosis via lumbar puncture was crucial, even with initial misinterpretations from EEG and CT scans.

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Immunology

    Background:

    • Chronic alcoholism can present with neurological symptoms, including hallucinations.
    • Herpes simplex encephalitis (HSE) is a severe infection of the brain, often with poor prognosis.
    • Diagnostic challenges in HSE can arise from initial presentations mimicking other conditions.

    Observation:

    • A 39-year-old man with chronic alcoholism experienced acoustic hallucinations and subsequent loss of consciousness.
    • Electroencephalogram (EEG) and CT scans suggested a brain tumor, but lumbar puncture revealed pleocytosis and intrathecal immunoglobulin G synthesis.
    • Analysis of the immunoglobulin G fraction showed locally produced herpes simplex virus antibodies.

    Findings:

    • The patient survived herpes simplex encephalitis with remarkable recovery, showing no impairment of consciousness or significant neurological deficits upon discharge.

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  • This represents a potentially unique case of surviving HSE outside a hospital setting with minimal sequelae.
  • The role of chronic alcoholism in potentially modifying the severity of HSE is noted as an open question.

    • Implications:

    • Lumbar puncture is critical for diagnosing HSE, especially when initial imaging is misleading.
    • The findings suggest that HSE may have a more variable course than previously understood.
    • Further research is needed to explore potential interactions between chronic alcoholism and HSE outcomes.