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Related Experiment Videos

Multiple androgenic abnormalities, including elevated free testosterone, in hyperprolactinemic women.

S P Glickman, R L Rosenfield, R M Bergenstal

    The Journal of Clinical Endocrinology and Metabolism
    |August 1, 1982
    PubMed
    Summary

    Hyperprolactinemic women often exhibit androgenic abnormalities, including elevated free testosterone and decreased testosterone-estradiol-binding globulin (TEBG). These hormonal imbalances appear linked to adrenal function and may be influenced by prolactin.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Hormone Metabolism

    Background:

    • Hyperprolactinemia is associated with symptoms like hirsutism and elevated dehydroepiandrosterone (DHA) and/or DHA sulfate (DHAS).
    • The specific androgenic abnormalities underlying these symptoms in hyperprolactinemic women require detailed investigation.

    Purpose of the Study:

    • To investigate the basis of hirsutism and elevated plasma DHA/DHAS in hyperprolactinemic women.
    • To compare androgen binding parameters and plasma androgen profiles in normal and hyperprolactinemic women.

    Main Methods:

    • Measured androgen binding parameters and plasma androgen profiles in normal (NL) and hyperprolactinemic (HYPRL) women.
    • Performed ACTH stimulation and dexamethasone (dex) suppression tests in subgroups.

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  • Assessed free and total testosterone, testosterone-estradiol-binding globulin (TEBG), DHAS, androstenedione, 11-deoxycortisol, and dihydrotestosterone (DHT).

    • Main Results:

    • Higher free testosterone levels in HYPRL women, linked to significantly lower plasma TEBG.
    • Elevated plasma DHAS, androstenedione, and 11-deoxycortisol observed in HYPRL women.
    • Lower plasma total dihydrotestosterone (tDHT) in HYPRL women, with normal free DHT and reduced tDHT to precursor ratios.

    Conclusions:

    • Approximately 40% of hyperprolactinemic women exhibit androgenic abnormalities, most commonly elevated free testosterone.
    • Depressed TEBG and elevated DHAS levels were less frequent findings.
    • Findings suggest an ACTH dependency of these abnormalities, potentially influenced by prolactin's effect on TEBG.