Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

S G Amara, V Jonas, M G Rosenfeld

    Nature
    |July 15, 1982
    PubMed
    Summary

    Alternative RNA processing of the calcitonin gene produces distinct mRNAs. This study proposes developmental regulation of RNA processing enhances neuroendocrine gene expression diversity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.

    Molecular psychiatry·2016
    Same author

    Pancreaticoduodenectomy for primary pancreatic lymphoma.

    Gastrointestinal cancer research : GCR·2012
    Same author

    PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis.

    Cell death and differentiation·2011
    Same author

    Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation.

    Cell death and differentiation·2009
    Same author

    The rapid identification of Clostridium perfringens as the possible aetiology of a diarrhoeal outbreak using PCR.

    Epidemiology and infection·2007
    Same author

    Pitx genes during cardiovascular development.

    Cold Spring Harbor symposia on quantitative biology·2003

    Area of Science:

    • Neuroendocrinology
    • Molecular Biology
    • Gene Expression

    Background:

    • The calcitonin gene undergoes alternative RNA processing.
    • This processing generates distinct messenger RNA (mRNA) molecules.

    Purpose of the Study:

    • To investigate the differential expression of calcitonin gene products.
    • To propose a model for developmental regulation of RNA processing in neuroendocrine gene expression.

    Main Methods:

    • Analysis of RNA transcripts from the calcitonin gene.
    • Comparison of mRNA prevalence in different tissues (thyroid and hypothalamus).

    Main Results:

    • Calcitonin mRNA is predominant in the thyroid gland.
    • Calcitonin gene-related peptide (CGRP)-specific mRNA predominates in the hypothalamus.

    Related Experiment Videos

    Conclusions:

    • Alternative RNA processing diversifies gene expression.
    • Developmental regulation of RNA processing plays a key role in neuroendocrine systems.