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Cholecystokinin in the central nervous system.
Peptides
|January 1, 1981
Summary
Researchers characterized cholecystokinin (CCK)-like molecules in the central nervous system using HPLC and RIA. The sulfated octapeptide is the predominant CCK form, with highest concentrations in the cortex and striatum.
Area of Science:
- Neuroscience
- Neurochemistry
Background:
- Cholecystokinin (CCK) is a peptide neurotransmitter found in the central nervous system.
- Understanding the distribution and forms of CCK is crucial for elucidating its functions.
Purpose of the Study:
- To characterize CCK-like molecules in the central nervous system.
- To determine the distribution of CCK in specific brain regions.
Main Methods:
- High-performance liquid chromatography (HPLC)
- Radioimmunoassay (RIA)
Main Results:
- The major CCK form identified was the sulfated octapeptide.
- CCK was unevenly distributed, with highest levels in the cortex and striatum.
- CCK-containing fibers project to the posterior pituitary and caudate nucleus, while hippocampal CCK is intrinsic.
Conclusions:
- The sulfated octapeptide is the primary CCK molecule in the brain.
- Specific brain regions exhibit distinct CCK innervation patterns.
- CCK binding sites are present in various brain structures, including the posterior pituitary, caudate nucleus, and hippocampus.