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Dynorphin-(1-13), dopamine and feeding in rats
Pharmacology, Biochemistry, and Behavior
|May 1, 1982
Summary
Dopamine agonists and opioid peptides stimulate feeding, with interactions between these systems. Satiety factors like bombesin, calcitonin, and cholecystokinin-octapeptide modulate these feeding responses.
Area of Science:
- Neuroscience
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Dopamine and opioid systems are implicated in regulating food intake.
- Understanding the interplay between these neurotransmitter systems is crucial for comprehending feeding behaviors.
Purpose of the Study:
- To investigate the role of dopaminergic and opioid pathways in initiating feeding behavior.
- To examine the modulatory effects of satiety factors on drug-induced feeding.
Main Methods:
- Intraventricular administration of dopamine agonist bromergocryptine and opioid peptide dynorphin-(1-13) to induce feeding in animal models.
- Administration of dopamine antagonist haloperidol and opioid antagonist naloxone to assess their inhibitory effects.
- Testing the influence of satiety factors including bombesin, cholecystokinin-octapeptide (CCK-8), thyrotropin-releasing hormone (TRH), and calcitonin on feeding responses.
Main Results:
- Bromergocryptine and dynorphin-(1-13) reliably induced feeding.
- Haloperidol and naloxone inhibited feeding induced by both bromergocryptine and dynorphin-(1-13).
- Bombesin inhibited feeding induced by both agents, while calcitonin and CCK-8 inhibited bromergocryptine-induced feeding but not dynorphin-(1-13)-induced feeding. TRH had no effect.
Conclusions:
- There is a significant interaction between dopaminergic and opioid systems in the regulation of food intake.
- Dopamine may initiate feeding behaviors like chewing, while opiates might regulate the ingestion process.
- Specific satiety factors differentially modulate dopaminergic and opioid-mediated feeding.