Primary renal tumors in nonhuman primates.

Area of Science:

• Veterinary Pathology
• Primate Oncology
• Comparative Pathology

Background:

• Primary renal tumors are infrequently documented in nonhuman primates.
• Understanding the spectrum and characteristics of these tumors is crucial for comparative oncology and primate health management.

Purpose of the Study:

• To characterize the incidence, histologic types, and clinical signs associated with primary renal tumors in a cohort of nonhuman primates.
• To review and synthesize findings with previously reported cases.

Main Methods:

• Histopathologic examination of renal tumors from 17 nonhuman primates.
• Review of clinical records for presenting signs and tumor characteristics.
• Compilation and analysis of 30 previously reported cases of primary renal tumors in nonhuman primates.

Main Results:

• Ten cases of renal carcinoma, four of renal adenoma, and other rare tumors were identified in the 17 primates.
• Clinical signs frequently observed included anorexia, lethargy, weight loss, depression, and dehydration.
• Tumor sizes ranged from 0.1 to 10.0 cm, with various histologic growth patterns observed in neoplasms of tubular cell origin.

Conclusions:

• Renal tumors, particularly carcinoma and adenoma, occur in nonhuman primates and present with common systemic clinical signs.
• Histologic diversity exists within primate renal neoplasms.
• This study contributes to the understanding of primate renal pathology and comparative oncology.