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Autosomal phosphoglycerate kinase linked to mouse major histocompatibility complex
Molecular & General Genetics : MGG
|January 17, 1978
Summary
The mouse phosphoglycerate kinase-2 (Pgk-2) gene is located near the major histocompatibility complex on chromosome 17. This gene
Area of Science:
- Genetics
- Immunology
- Biochemistry
Background:
- The phosphoglycerate kinase-2 (Pgk-2) gene encodes a specific form of phosphoglycerate kinase found exclusively in mouse testes.
- The major histocompatibility complex (MHC) on mouse chromosome 17 is a critical region for immune function and contains numerous genes.
Purpose of the Study:
- To determine the precise chromosomal location of the mouse Pgk-2 locus.
- To investigate the genetic linkage between Pgk-2 and the MHC on chromosome 17.
Main Methods:
- Analysis of genetic markers and strain distribution patterns in 103 inbred and congenic mouse strains.
- Comparative mapping of the Pgk-2 locus relative to known MHC and chromosome 17 loci (H-2, Qa-1, Qa-2, T1a).
Main Results:
- The mouse Pgk-2 locus is closely linked to, but not within, the MHC on chromosome 17.
- Pgk-2 is located distal to H-2, Qa-1, and Qa-2, and shows close association with the T1a locus.
- The strain distribution pattern of Pgk-2 across 103 mouse strains is documented.
Conclusions:
- The Pgk-2 locus is a distinct genetic entity situated near the MHC on mouse chromosome 17.
- The polymorphism of Pgk-2 among inbred mouse strains makes it a valuable marker for future genetic linkage studies.