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Pubertal development: normal, precocious and delayed.

J R Ducharme, R Collu

    Clinics in Endocrinology and Metabolism
    |March 1, 1982
    PubMed
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    Puberty is a neuroendocrine continuum programmed prenatally, involving complex hormonal interactions. This review details pubertal development, its regulation, and associated disorders, offering insights into sexual maturation.

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Reproductive Biology

    Background:

    • Puberty is a developmental continuum initiated prenatally, culminating in autoregulated hormonal secretions and sexual maturity.
    • This process relies on a balance between central nervous system (CNS) neurohormones, neurotransmitters, pituitary gonadotropins, and end-organ responses.
    • Gonadal sex steroids (testosterone and estradiol) mediate biological actions via specific receptors.

    Purpose of the Study:

    • To review neuroendocrine mechanisms governing pubertal development and progression to sexual maturity.
    • To elucidate the continuum of puberty from prenatal programming to adult autoregulation.
    • To discuss clinical manifestations, abnormalities, and management of pubertal disorders.

    Main Methods:

    • Review of existing concepts on neuroendocrine mechanisms of puberty.

    Related Experiment Videos

  • Analysis of the hypothalamic-pituitary-gonadal axis (HPGA) regulation, including feedback mechanisms.
  • Description of clinical presentations and diagnostic approaches for pubertal abnormalities.

    • Main Results:

    • Pubertal development is a continuum regulated by the HPGA, influenced by CNS factors and gonadal steroids.
    • The gonadostat system exhibits changing sensitivity to negative and positive feedback, crucial for development and ovulation.
    • Adrenal androgens likely play a supportive role in pubertal progression.

    Conclusions:

    • Understanding the neuroendocrine continuum of puberty is essential for diagnosing and managing disorders.
    • Precocious puberty has different etiologies in girls (idiopathic) and boys (lesions).
    • Delayed puberty and gonadal insufficiency require thorough investigation and tailored treatment.