Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioid plasma levels during labour.

F Facchinetti, G Centini, D Parrini

    Gynecologic and Obstetric Investigation
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen.

    Anticancer research·2001
    Same author

    Serum allopregnanolone in women with postpartum "blues".

    Obstetrics and gynecology·2001
    Same author

    The use of a starting dose of recombinant follicle stimulating hormone for controlled ovarian hyperstimulation: a randomized pilot study.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Ovarian follicular fluid contains immunoreactive estriol: lack of correlation with estradiol concentrations.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Dose-response efficacy of a new estradiol transdermal matrix patch for 7-day application: a randomized, double-blind, placebo-controlled study. Italian Menopause Research Group.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same journal

    Vaginal Estrogen for Urinary Tract Infection Prevention: A Narrative Review of Evidence, Guidelines, and Regulatory Gaps.

    Gynecologic and obstetric investigation·2026
    Same journal

    Auxiliary data as surrogates for SCORE2 risk calculator inputs - design and methodology of the Frauenherzen study in apparently healthy women aged 40-69 years.

    Gynecologic and obstetric investigation·2026
    Same journal

    Comparison of colpocleisis and long-term pessary therapy in the management of severe pelvic organ prolapse - A retrospective observational study.

    Gynecologic and obstetric investigation·2026
    Same journal

    Société Suisse de Gynécologie et d'Obstétrique (SGGG) Congress Congrès annuel de Gynécologie Suisse.

    Gynecologic and obstetric investigation·2026
    Same journal

    Comparative Study of DHEA vs. Femarelle® on Menopausal Systemic and Genitourinary Syndrome.

    Gynecologic and obstetric investigation·2026
    Same journal

    The Role Of Dietary Supplements in The Management Of Endometriosis-Related Symptoms: Current Evidence Based on A Systematic Review Of Randomized Controlled Trials.

    Gynecologic and obstetric investigation·2026
    See all related articles

    During labor, plasma levels of beta-lipotropin (beta LPH) and beta-endorphin (beta EP) significantly increase, correlating directly with uterine contraction intensity. These opioid levels decrease postpartum.

    Area of Science:

    • Reproductive Endocrinology
    • Neuroendocrinology
    • Obstetrics

    Background:

    • Opioid peptides like beta-lipotropin (beta LPH) and beta-endorphin (beta EP) play roles in physiological processes.
    • Their involvement during human labor and delivery is not fully understood.

    Purpose of the Study:

    • To investigate the dynamic changes in plasma beta-LPH and beta-EP levels throughout labor and the puerperium.
    • To explore the relationship between these opioid levels and uterine activity during labor.

    Main Methods:

    • Studied 6 healthy pregnant women using external cardiotocography.
    • Collected blood samples hourly during labor and on postpartum day 5.
    • Quantified beta-LPH and beta-EP using radioimmunoassays after plasma extraction and chromatography.

    Related Experiment Videos

    Main Results:

    • Plasma beta-LPH and beta-EP levels progressively increased during labor, peaking 1 hour before delivery.
    • A significant correlation was found between beta-LPH and beta-EP plasma levels.
    • Opioid levels decreased significantly after placental delivery and further by postpartum day 5.
    • These opioid levels correlated significantly with uterine contractility force per hour.

    Conclusions:

    • Plasma concentrations of beta-LPH and beta-EP rise significantly during labor.
    • The increase in these opioid levels is directly associated with the intensity and frequency of uterine contractions.
    • Postpartum levels of beta-LPH and beta-EP return to baseline by the fifth day.