[Para-immunity after oral antigen administration]

The term "Paramunity" summarizes all non-pathogen specific mechanisms of the defence against infections in man and animal, such as phagocytosis, interference, antibiosis, activation of the lymphopoietic cell system and of lysosomal enzymes, stimulation of humoral factors etc. Examples for the induction of a paramunity are described. After an oral or inhalatory administration of polyvalent vaccines prepared from inactivated bacteria to mice, the rate of phagocytosis of the peritoneal or alveolar macrophages increased significantly. An oral application of inactivated dyspepsia coli bacteria, caused in mice a partial protection against a challenge with a strain of Rous-sarcoma. After a tenfold oral paramunization with the polyvalent vaccine "Dodecoral" consisting of 12 heat-inactivated strains of enterobacteriaceae, mice were protected against an oral infection with the parapoliomyelitis virus Col-SK.