Related Experiment Video

Updated: Oct 20, 2026

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions
12:17

An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions

Published on: May 8, 2017

[Penetration of ceftizoxime (FK 749) into the cerebrospinal fluid (author's transl)]

B Ruf

    Infection
    |January 1, 1982
    PubMed

    Insights

    Ceftizoxime effectively penetrates cerebrospinal fluid (CSF) in meningitis patients, reaching therapeutic levels after both bolus injections and infusions. Further research is needed to confirm clinical efficacy against various meningitis-causing pathogens.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Neurology

    Context:

    • Meningitis, a serious central nervous system infection, requires effective antibiotic penetration into the cerebrospinal fluid (CSF).
    • Ceftizoxime is a third-generation cephalosporin with broad-spectrum activity, but its CSF penetration and efficacy in meningitis require detailed pharmacokinetic evaluation.
    • Understanding drug concentration in CSF is crucial for optimizing treatment regimens and predicting clinical outcomes.

    Purpose:

    • To determine the concentration of ceftizoxime in the CSF and serum of patients with purulent or serous meningitis.
    • To evaluate the pharmacokinetic profile of ceftizoxime following different administration methods (bolus injection vs. infusion).
    • To assess the potential efficacy of ceftizoxime against common meningitis pathogens based on achieved CSF concentrations.

    Summary:

    • Ceftizoxime concentrations in CSF were measured in 27 meningitis patients after normalization of CSF cytology and chemistry.
    • Following a 2g bolus injection, mean CSF concentration was 0.87 mg/L at 2 hours. After a 2g/30min infusion, mean CSF concentrations were 0.32 mg/L at 1 hour and 0.99 mg/L at 2 hours.
    • Peak CSF concentrations of 4.3 mg/L (mean 1.78 mg/L) were observed 6 hours after a 2g bolus injection, suggesting potential for cumulative effects with repeated dosing.

    Impact:

    • The pharmacokinetic data suggest ceftizoxime may achieve effective concentrations in the CSF for treating meningitis.
    • Ceftizoxime is anticipated to be effective against a range of meningitis pathogens, excluding Staphylococcus sp., Pseudomonas sp., and some anaerobes.
    • Further clinical studies are necessary to validate the therapeutic effectiveness of ceftizoxime in meningitis patients.

    More Related Videos

    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations11:15

    Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

    Published on: July 24, 2021

    Amikacin Protection Assay for Quantification and Visualization of Escherichia coli Cell Invasion09:22

    Amikacin Protection Assay for Quantification and Visualization of Escherichia coli Cell Invasion

    Published on: July 3, 2026

    Related Concept Videos

    Viral Meningitis01:18

    Viral Meningitis

    Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
    Cryptococcal Meningitis01:27

    Cryptococcal Meningitis

    Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
    Brain Abscess l: Introduction01:26

    Brain Abscess l: Introduction

    A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...