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[Basic studies of cefotiam (author's transl)].

T Aoyama

    The Japanese Journal of Antibiotics
    |March 1, 1982
    PubMed
    Summary

    Cefotiam (CTM) pharmacokinetics in children show rapid serum level decline after IV injection and drip infusion, with half-lives around 1-1.2 hours. Urinary excretion averages 45% over 6 hours, with no bioactive metabolites detected.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Antibiotic Research

    Context:

    • Cefotiam (CTM) is a cephalosporin antibiotic.
    • Understanding CTM pharmacokinetics is crucial for pediatric dosing.
    • Basic pharmacokinetic studies provide foundational data for clinical application.

    Purpose:

    • To determine the serum levels and urinary excretion of cefotiam (CTM) in children following intravenous injection and drip infusion.
    • To assess the serum half-life and identify any bioactive metabolites of CTM.
    • To establish pharmacokinetic profiles for CTM in a pediatric population.

    Summary:

    • Following a single intravenous injection of 40 mg/kg CTM, serum levels declined rapidly with a beta-phase half-life of approximately 1.2 hours. Mean urinary excretion was 45.7% over 6 hours.
    • A 1-hour drip infusion of 40 mg/kg CTM resulted in a similar rapid decline in serum levels, with a beta-phase half-life of approximately 1.0 hour. Mean urinary excretion was 48.7% over 6 hours.
    • No bioactive metabolites of CTM were detected in serum or urine after administration at the studied dose.

    Impact:

    • Provides essential pharmacokinetic data for cefotiam (CTM) in pediatric patients.
    • Informs appropriate dosage adjustments and administration routes for CTM in children.
    • Contributes to the safe and effective use of cefotiam (CTM) in pediatric infectious disease management.

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