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[Basic studies of cefotiam (author's transl)]
Insights
Cefotiam (CTM) pharmacokinetics in children show rapid serum level decline after IV injection and drip infusion, with half-lives around 1-1.2 hours. Urinary excretion averages 45% over 6 hours, with no bioactive metabolites detected.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Antibiotic Research
Context:
- Cefotiam (CTM) is a cephalosporin antibiotic.
- Understanding CTM pharmacokinetics is crucial for pediatric dosing.
- Basic pharmacokinetic studies provide foundational data for clinical application.
Purpose:
- To determine the serum levels and urinary excretion of cefotiam (CTM) in children following intravenous injection and drip infusion.
- To assess the serum half-life and identify any bioactive metabolites of CTM.
- To establish pharmacokinetic profiles for CTM in a pediatric population.
Summary:
- Following a single intravenous injection of 40 mg/kg CTM, serum levels declined rapidly with a beta-phase half-life of approximately 1.2 hours. Mean urinary excretion was 45.7% over 6 hours.
- A 1-hour drip infusion of 40 mg/kg CTM resulted in a similar rapid decline in serum levels, with a beta-phase half-life of approximately 1.0 hour. Mean urinary excretion was 48.7% over 6 hours.
- No bioactive metabolites of CTM were detected in serum or urine after administration at the studied dose.
Impact:
- Provides essential pharmacokinetic data for cefotiam (CTM) in pediatric patients.
- Informs appropriate dosage adjustments and administration routes for CTM in children.
- Contributes to the safe and effective use of cefotiam (CTM) in pediatric infectious disease management.
Abstract:
The basic studies of cefotiam (CTM) were performed, and the following results were obtained. 1. One shot intravenous injection of 40 mg/kg of CTM (1) Serum levels: The mean levels of CTM in 3 children were 133.9 micrograms/ml after 15 minutes, 71.5 micrograms/ml after 30 minutes 32.6 micrograms/ml after 1 hour, 9.2 micrograms/ml after 2 hours, 2.5 micrograms/ml after 4 hours, 0.9 microgram/ml after 6 hours. The serum half life of CTM was approximately 1.2 hours on beta-phase. (2) Urinary excretion: The mean urinary excretions were 39.4% over 3 hours, 44.7% over 4 hours, 45.7% over 6 hours. 2. 1 hour-drip infusion of 40 mg/kg of CTM (1) Serum levels: The mean serum levels of CTM in 4 children were 140.1 micrograms/ml at immediately after drip infusion was completed, 10.6 micrograms/ml after 1 hour, 3.8 micrograms/ml after 2 hours, 1.4 micrograms/ml after 3 hours, 0.5 microgram/ml after 5 hours. The serum half life of CTM was approximately 1.0 hour on beta-phase. (2) Urinary excretions: The mean urinary excretions were 42.9% over 2 hours, 48.0% over 4 hours, 48.7% over 6 hours. 3. Bioactive metabolite in serum and urine: No bioactive metabolites were observed in either serum or urine after administration of 40 mg/kg of CTM.