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Related Experiment Videos

Neural plasticity: Part 2. Postnatal maturation and function-induced plasticity.

B Bishop

    Physical Therapy
    |August 1, 1982
    PubMed
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    Newborns have most neurons, but central nervous system (CNS) function differs greatly from adults. Postnatal development, influenced by function and experience, is crucial for proper CNS maturation and avoiding deficits.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Central Nervous System (CNS) Development

    Background:

    • Most neuronal cell division, migration, and specialization are complete at birth.
    • Mammals are born with a near-complete set of neurons, yet functional capabilities are immature.
    • Prenatal maturational processes extend into the postnatal period.

    Purpose of the Study:

    • To describe key postnatal maturational mechanisms of the CNS.
    • To illustrate the role of function and experience in CNS development.
    • To highlight the importance of proper postnatal maturation sequence and rate.

    Main Methods:

    • Review of postnatal CNS maturational phenomena.
    • Analysis of selected examples demonstrating the impact of function and experience.

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  • Comparison of newborn and adult CNS functional capabilities.
  • Main Results:

    • Postnatal maturation involves ongoing neural development and refinement.
    • Function and environmental experience significantly influence CNS development trajectories.
    • Deviations in postnatal maturation can lead to adult CNS deficits.

    Conclusions:

    • Postnatal CNS development is a critical period for functional maturation.
    • Experience-dependent mechanisms are vital for shaping neural circuitry.
    • Understanding these processes is key to preventing neurological disorders.